Antioxidants has been utilized in the management of oxidative stress related pathologies specifically sickle cell disorder. Here we analyze the antioxidants potential of Ficus thonningii, Jatropha Tanjorensis and Justicia carnea and their pure isolates using DPPH, hydroxyl radical scavenging activity, reducing power, FRAP and phosphomolybdemum antioxidant. The extracts were isolated and purified using the harbone method and the structures of each isolate were elucidated using NMR analysis. The results of our analysis validate these plants use as medicinal and nutraceuticals in the management of sickle cell patients in Ebonyi state. The results of our analysis indicate that all the analyzed plant extracts showed a variable antioxidant activity, whereas the pure isolates had better antioxidant activity than the crude extract and confirms the use of these plants extracts in the management of sickle cell disorder. Therefore, our findings suggest that Ficus thonningii, Jatropha Tanjorensis and Justicia carnea and their pure isolates are potential source of natural antioxidant in preventing oxidative stress related degenerative diseases in sickle cell anemia patients.