Brucellosis is a major common to humans and different animal species zoonoses. The bacteria belonging to the genus Brucella, they cause a multitude of symptoms in cattle, but the most attractive is the abortion that occurs mainly in the last third of gestation. The objective of this work is on the one hand the study of seroprevalence of the disease with serological tests that are buffered antigen test and complement fixation as a confirmatory method, and secondly, the development of a strategy adapted to the epidemiological situation. Dice 2000 until 2005, the wilaya of Constantine recorded prevalence above 1%. So the disease becomes enzootic great with a heterogeneous distribution across the various municipalities. The number of households experiencing a significant increase after the peak of 2001 and continues to grow even in the first half of the year 2007. The best strategy is vaccination of all cattle in the province with the RB51 vaccine, which has a very high protective efficacy.