Scholars Research Library

Scholars Research Library

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Der Pharmacia Lettre


Evaluation of Analgesic Activity of Hydroalcoholic Extract of Cinnamomum zeylanicum Bark in Albino Rats

Author(s): Rajendra Kumar Swain, Bimlendu Chowdhury and Bhanoji Rao ME

The hydroalcoholic extract of Cinnamomum zeylanicum (HAECZ) bark was evaluated for its analgesic activity in albino rats. The HAECZ bark was evaluated for its toxicity study and priliminary phytochemical analysis using standard methods. HAECZ bark was evaluated for its analgesic activity at a dose of 100, 200 and 400 mg/kg, p.o. by using Tail immersion and Hot plate method in Wister albino rats. HAECZ bark showed no toxicity up to 1000 mg/kg body weight and the preliminary phytochemical study indicates presence of carbohydrates, terpenoids, tannins, saponins, flavonoid, glycosides and steroids. The extract showed significant and dose dependent analgesic activity in tail immersion test whereas in hot plate test it showed significant activity at 100 and 400 mg/kg body weight respectively. HAECZ bark showed analgesic activity in albino rats and was comparable with pentazocin.