Objective: Baeolepis nervosa is endemic to Western Ghats, Nilgiris and is used by the tribes of nilgiri hill’s namely “Irulas”. The present study was done to evaluate the B. nervosa, a novel study of this plant. Material and methods: The B. nervosa were undergone photomicrography, to study the microscopical character of the plant. To evaluate the B. nervosa for anti-microbial properties for both Bacteria and Fungi. The Fractionation was carried out using (Pet ether, Chloroform, ethyl acetate) the MeOH extract, and these fractions were carried out for anti-oxidant potentials. Results: The transverse section of leaves and stem of B. nervosa has been analyzed and reported. The preliminary phytochemical analysis confirms the presence of alkaloids, flavonoids, phenols, steroids, tannis and triterpenes. The zone of inhibition for anti-microbial activity showed results only in gram –ve (E. coli) of B. nervosa leaf and in fungi it showed in A. niger of both B. nervosa leaf and stem. The aqueous extract showed good IC50 value for B. nervosa leaf (IC50 – DPPH- 52.75μg/ml, ABTS- 45.14 μg/ml, NO2- 64.32 μg/ml & H2O2- 70.80 μg/ml) and Ethyl acetate extracts showed good IC50 value for B. nervosa stem (IC50 – DPPH- 69.19 μg/ml, ABTS- 59.91 μg/ml, NO2- 54.30 μg/ml & H2O2- 56.06 μg/ml). Conclusion: It can be concluded that B. nervosa has shown a good activity against anti-microbial as well as in anti-oxidant studies.