Depressive disorder is a prevalent psychiatric disorder, which affects 21% of the world population. The presently using drugs can impose a variety of side effects including cardiac toxicity, hypopiesia, sexual dysfunction, body weight gain, and sleep disorders. Carissa macrocarpa was investigation for antidepressant activity. Antidepressant activity of ethanolic extract of Carissa macrocarpa was investigated by using Tail suspension test, Forced swim test and locomotor activity models. Fluoxetine and Imipramine were used as reference standards.