The study was designed to examine the invitro antioxidant activities of various extracts of aerial parts of Chomelia asiatica. The antioxidant activity was evaluated by DPPH (,-diphenyl-β-picrylhydrazyl) radical scavenging activity, Super Oxide Anion Scavenging Activity with reference standard Rutin, Quercetin respectively and estimate the amount of total phenol. The ethyl acetate extract of Chomelia asiatica was found to more effective in the DPPH radical scavenging activity. The IC50 of the ethyl acetate extract of Chomelia asiatica and Rutin were found to be 460μg/ml and 480μg/ml respectively. An IC50 value was found that ethyl acetate extract of Chomelia asiatica is more effective in scavenging superoxide radical than that of methanol and petroleum ether extract. But when compare to the all the three extracts with Quercetin (standard), the ethyl acetate extract of the Chomelia asiatica showed the similar result. In addition, the ethyl acetate extract of Chomelia asiatica was found to contain a noticeable amount of total phenols, which play a major role in controlling antioxidants. It is concluded that a aerial parts of ethyl acetate extract of Chomelia asiatica, which contains large amounts of phenolic compounds, exhibits high antioxidant and free radical scavenging activities. These in vitro assays indicate that this plant extracts is a significant source of natural antioxidant, which might be helpful in preventing the progress of various oxidative stresses.