Klebsiella pneumoniae is one of the potent pathogen causing noscomial infection in immunocompromised patients resulting in severe urinary tract and pneumonia infection. In recent years ESBL strains have been produced which shows multidrug resistant pattern in the most of the cases such as patients suffering from severe lung infection and UTI. In the present clinical isolates were procured from clinical laboratory and tested for ESBL producing strains by synergistic disc diffusion technique. Among the 50 isolates, 24 strains were ESBL producers which were resistant to both ceftazidime and cefotaxime. The obtained results show resistance towards the third generation cephalosporin drug.