Flurbiprofen, a propionic acid derivative, is a non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic activity. Poor water solubility is its constraint for its oral bioavailability. The rationale of the present study is to enhance the solubility and bioavailability of the drug by using superdisintegrants like crosspovidone, sodium starch glycolate and β cyclodextrin. In the present study attempt has been made to prepare fast dissolving tablets of flurbiprofen using superdisintegrants, β-cyclodextrin inclusion complex with drug. The inclusion complex was prepared by physical mixture method and was further formulated as tablets by using direct compression method. The pure drug was evaluated by flow properties. The pure drug and drug excipient complex was characterized by FTIR and tablets were evaluated for hardness, %friability, wetting time, water absorption ratio, disintegration, drug content and in vitro dissolution studies. From F1 to F12 formulations it was concluded that F8 formulation was best and the best formulation was compared with the marketed tablet flurbiprofen uncoated tablet of 50 mg, and the drug release from marketed tablet was less compared with the F8 formulation.
