The objective of the proposed research work is to prepare and evaluate the mouth dissolving/disintegrating tablets (MDTs) of losartan Potassium, which avoid the first-pass metabolism, improved the dissolution rate and enhance the bioavailability. Losartan potassium is an angiotention receptor antagonist, used in the management of hypertension. Mouth dissolving tablets (MDTs) were prepared by direct compression method by using different concentrations of superdisintegrant like Crospovidone, Sodium Starch Glycolate , Croscarmellose sodium, Micro Crystalline Cellulose and evaluated for physicochemical evaluation parameter such as hardness, friability, weight variation, drug content uniformity, water absorption ratio, wetting time, in-vitro, in-vitro dissolution studies. The twelve formulations, F1-F9 were formulated and among these formulations, F3 was optimized. The hardness, friability, weight variation and drug content were found to be within pharmacopeias limits. The In vitro drug release from formulation containing super disintegrant CP was found between 87.64±0.36 to 98.75±0.61 in 10 min and the maximum drug release was found with F3 formulation. The disintegration studies shown that the all formulations disintegrated in less than 1 minute. The formulation F3 shown less disintegration time of 17 seconds. The croscarmellose sodium and sodium starch glycolate shown more disintegration time than crospovidone. An accelerated stability study on optimized formulation was performed. The formulation was found to be stable, there was no change in the hardness, friability, disintegration time, and In-vitro drug release pattern. DSC and FTIR data revealed that no interactions takes place between the drug and polymers used in the optimized formulation. In conclusion, it can be stated that the objective of the study has been achieved. From the above study the formula used for F3 formulation was concluded as an optimized formulation due to its less disintegration time and good % drug release when compared with other formulations.