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Formulation and evaluation of oral fast disintegrating tablets by using amlodipine besylate solid dispersion by direct compression method | Abstract
Scholars Research Library

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Der Pharmacia Lettre

Abstract

Formulation and evaluation of oral fast disintegrating tablets by using amlodipine besylate solid dispersion by direct compression method

Author(s): Ganji Amarnath Reddy, Balajia, Naveen KJ, Rajesh BS and Yedla Anil Chowdary

Amlodipine Besylateis a major calcium channel blocker for the treatment of hypertension. In the present study it reveals that the oral fast disintegrating tablet of Amlodipine Besylateusing different combination of superdisintegrants like Croscarmellose sodium (Ac-Di-Sol), Sodium Starch Glycolate (Primogel), Cross Povidone (Polyplasdone) and got better bioavailability within a short duration of time with different formulations. Although oral disintegrating tablets are much useful in the cases of geriatric, pediatric and travelling patient because no water required for the administration. For the masking of bitter taste we used aspartame as sweetening agent. In this study instead of drug we prepared drug solid dispersion so that drug’s solubility we enhanced. Finally F3 and F9 formulation showing more drug release it was found to be 96.67% and 97.33% respectively within 15 min of time.


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