Scholars Research Library

Scholars Research Library

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Der Pharmacia Lettre

Abstract

Formulation and Evaluation of Solid binary systems of an Antipsychotic Drug by Using a modified Carrier

Author(s): N.L Prasanthi, N. Rama Rao, S.S.Manikiran

The aim of the study was to formulate and evaluate solid binary systems of the poorly watersoluble novel antipsychotic drug ziprasidone hydrochloride. The solid binary systems were prepared by using a new carrier (modified starch such as starch phosphate) for improving the dissolution properties. Starch phosphate was prepared by a reported method. The solid binary systems were prepared by kneading method in different drug to carrier molar ratios (1:1, 1:3, 1:9 and 1:19). Evaluation of the solid binary system was performed using dissolution studies, Differential thermal analysis, Infrared Spectroscopy and X-ray powder diffraction studies. All the solid binary systems showed dissolution improvement when compare to pure drug and physical mixture to varying degrees, binary systems prepared by kneading method in 1:9 drug to carrier ratio exhibited the highest drug release. Mathematical modeling of in vitro dissolution data indicated the best fitting with Korsemeyer-Peppas model and the drug release kinetics primarily as Fickian diffusion.
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