Scholars Research Library

Scholars Research Library

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Der Pharmacia Lettre


Formulation and In Vitro Evaluation of Pulsatile Colon Drug Delivery System of Piroxicam using 32 Factorial design

Author(s): Suresh Bandari, Krishna Sanka, Raju Jukanti, Prabhakar Reddy Veerareddy

The aim of the present investigation was to develop colon specific double cross linked alginatechitosan blend gel beads for pulsatile release. A 32 factorial design was employed to study the influence of two independent variables amount of piroxicam (X1), amount of chitosan (X2) on dependent variables, encapsulation efficacy (YEE), amount of drug release at 5th hour (Y5) and amount of drug release at 6th hour (Y6). The prepared colon specific pulsatile beads were evaluated for particle size and invitro drug release studies. Drug polymer interaction studies were determined by fourier transform infrared (FTIR) spectroscopy. The surface characteristics and morphology was determined by scanning electron microscopy (SEM). The check point batch was prepared and the contour and 3D plots were also presented. It was concluded that the desired colon specific pulsatile release was obtained with alginate-chitosan blend gel double cross linked beads.