Scholars Research Library

Scholars Research Library

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Der Pharmacia Lettre

Abstract

Formulation development and process comparison of different compressed oral disintegrating tablets

Author(s): Venkata Ramana Reddy S, Sathyanarayana Dondeti, Manavalan R, Sreekanth J

The aim of the present investigation was to develop simple oral disintegrating tablets (ODT) for industrial purpose with different category of drugs like granisetron hydrochloride, memantine hydrochloride, amlodipine besylate, desloratadine, zaleplon and risperidone using different formulation and process. Granisetron hydrochloride (GRN), memantine hydrochloride (MEM), amlodipine besylate (AML) and zaleplon (ZAL) drugs are low bitter and low dose drugs. ODT of these drugs were prepared to using direct compression tablets techniques with simple taste and flavors enhancers. ODT of desloratadine (DES) and risperidone (RIS) were prepared using wet granulation tablets technique with different taste masking agents, taste and flavor enhancers, because these two drugs are highly bitter with low dose drugs. Simple taste and flavor enhancers were not sufficient to mask bitterness of these drugs. Amberlite was used as a taste masking agent, Mannitol was used as a diluents, Acesulfame potassium, aspartame and peppermint was used as a flavoring agent. The results revealed that the tablets containing taste masking had a good palatability for the patients. It was concluded that all the ODTâ??s with improved taste masking and dissolution could be prepared by simple compressed tablet technique with suitable excipients. This work helped in understanding the effect of oral disintegrating tablets formulation and processing comparison of compressed tablet technique, especially the disintegrating and taste masking agents on the drug taste masking, disintegration time and release profile. The present study demonstrated potentials for rapid disintegration in oral cavity with out water, improved taste masking and patient compliance
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