The current research work deals with the formulation and evaluation of diacerein loaded buccal strips followed by optimization and quality control. Diacerein is also known as diacetylrhein, is a slow-acting drug which belongs to anthraquinone class and is used to treat joint diseases such as osteoarthritis. It works by inhibiting interleukin-1 beta. Ten bathces of buccal atrips were prepared using polymers like HPMC, Eudragit, sodium alginate, and sodium CMC in varying proportions. A total amount of upto 4% of the polymers were used in combination. The amount 4% wwas optimized by trial batches ranging from 0.5% to 6% of the polymer amount. All the formulations were subjected for quality control parameters like folding endurance, content uniformity, swelling index, surface pH, mucoadhesive strength studies, invitro permeation, ex vivo permeation and stability studies. The results were analysed and on the basis of the resullts optimized formulations was selested. The prepared formulations showed zero order controlled release following super case II transport mechanism suggesting controlled release by swelling and erosion mechanism. The formulations were found to be stable and good platform for management of osteoarthritis.