Background and objectives: The Scrophularia striata plant has traditionally been used among people inhabited the Zagros as healing of wound and infection. Therefore, the aim of this study was to evaluate the wound healing effect of aqueous and hydroalcholic extract of Scrophularia striata on the oxidative stress indices and ethanol-induced gastric ulcers in rats. Material and methods: After collecting and drying the plants, hydroalcholic and aqueous extracts were prepared by maceration method. 60 male rats were randomly divided into control, omeprazole, and four groups receiving aqueous and hydroalcholic extracts (100 & 400 mg / kg) and were treated for two weeks. Then serumic levels of total antioxidant capacity (TAC), super oxide dismutase (SOD), and malondialdehyde (MDA) were measured as well as the stomach of rats was examined macroscopically. Results: The results have demonstrated that administration of the extract was effective on the MAD, SOD, TAC, and the size and number of ulcers (P <0.01), so that SOD and MAD has decreased with increasing dose of the extract but increased with TAC. Hydroalcholic and aqueous extracts reduced the number and size of gastric ulcersbut there was no difference between them. In addition, by increasing the dose of extract, the number and size of ulcers decreases. Discussion and conclusions: Administration of the Scrophularia striata extract could reduce indices of oxidative stress. Considering the macroscopic studies on the stomach, the herbal effective components probably stimulate collagen synthesis and faster wound contraction, angiogenesis, vascular dilatation, and also reduces inflammation, edema, bleeding and scarring. Further studies are needed to determine the mechanism of the therapeutic effect of the extract.