Der Pharmacia Lettre
Sandip D. Chavan, Rohan S. Ghodake, Sandeep B. Patil, Nilofar S. Naikwade
Carbon tetrachloride (CCl4) pharmacological tool to produce liver damage reduced the urinary
excretion of ascorbic acid in rats. Silymarin and extract of Butea monosperma (Lam) Taub
(shown to be hepatoprotective substances) prevented the CCl4 induced reduction of ascorbic
acid excretion in urine. The results indicate that silymarin, Aqueous and Methanolic Extracts of
leaves of Butea monosperma (Lam) Taub reduced the hepatic damage caused by i.p.
administration of CCl4 as compared to control based on the urinary ascorbic acid levels.