Soil is considered as the hot-spot region of beneficial plant-microbe association. A wide range of soil microbial categories like nitrogen-fixing bacteria, ecto and endo-mycorrhizal fungi and plant growth-promoting bacteria and fungi are seemed to be associated with this beneficial plant-microbe association. The soil microbes confer increased plant growth and productivity against the root pathogenic fungi, bacteria, viruses and nematodes by a wide variety of mechanisms like phosphate solubilization, siderophore production, biological nitrogen fixation, phytohormones production, exhibiting antifungal activity, production of volatile organic compounds (VOCs), induction of systemic resistance (ISR) etc. Beneficial soil microbes have also been engineered to interfere with the synthesis of stressinduced hormones such as ethylene that can retard the root growth in plants and to produce antibiotics and lytic enzymes that predominantly exhibited their activity against the soil-borne root pathogens. However, a change in the type, distribution and coverage of soil microbial populations may occur with the changing climate scenario. Agricultural land-use systems along with proper exploitation of beneficial microbial strains are, therefore, regarded as one of the most effective climate change resilience farming systems as it promotes the proper management of soil, water, biodiversity and local knowledge, thereby, acting as a good alternatives for adaptation to climate change. In the present review, an attempt has been made to critically review the possible intervention of climate change on beneficial soil microbes associated with the plants.