Lead (Pb) pollution has been considered as a major threat for human health. Lead may be able to induce inflammatory cascades in various tissues. Allergic asthma and neurodegenerative diseases inflammatory diseases that the association between lead exposure and occurrence of these problems has been proven. The aim of present review is to summarize literature on the effects of lead exposure and occurrence of neurodegenerative problems. This study indicates lead may causes neurodegenerative diseases via direct and indirect induction of inflammatory cascades.