Secondary infertility may have severe complications for the involved couples, especially for the women. It thought menstrual-reproductive factors could influence the fertility status of the couples. This study was aimed to comparison the socio-demographic and menstrual-reproductive factors between secondary infertile and fertile women in southeastern Iran. In this case-control study, 125 secondary infertile women as case group and 140 fertile women as control group were investigated in 2015. The subjects were selected from the fertility clinics and private office of the gynecologists in Zahedan, southeast of Iran. A structured questionnaire including reproductive history and socio-demographic variables was used to data collection. The data were analyzed in Stata.12 software using Chi-square and multiple logistic regression with Hosmer & Lemeshow method. The mean age of marriage, age at first pregnancy and age at first menarche in secondary infertile women was more than in fertile women, but only the difference of age at first menarche (P=0.0001) were statistically significant. Multiple logistic regression model showed that the secondary infertile women were more likely to have had the first conception in older age (OR = 1.71, CI=1.12-5.3) and irregular menses (OR=3.91, CI= 1.5-6.7). The main finding of this study is that obstetric events contribute approximately equally to secondary infertility in Zahedan. Socio-demographic and menstrualreproductive factors not only influence the obstetric events, but directly effect on fertility via other paths. However, health promotion to improvement of menstrual-reproductive and high quality counseling of women at risk are likely to decrease secondary infertility.