An innovative treatment option for cancer, bacteria-mediated cancer therapy has the ability to target a wide range of tumors, may be administered through a variety of channels, is flexible in its delivery, and supports the host’s immune responses. The therapeutically injected bacteria can be seen, and molecular imaging of bacterium-mediated cancer therapy demonstrates that the therapeutic bacteria were successfully delivered to the target lesion. Bacteria-specific imaging is difficult because to a number of obstacles, such as the requirement to distinguish between a therapeutic bacterial infection and inflammation or other pathologic diseases. The creation of bacteria-specific targets that can be linked to imaging assays is required to fully fulfill the potential of bacteria-specific imaging. The present state of bacterial imaging methods is discussed in this review, along with the benefits and drawbacks of various imaging modalities. We also discuss possible imaging targets for microorganisms and associated applications
