This review explained the microwave assisted synthesis of biologically active Chalcone. Recently the microwave has become the useful nonconventional source for the organic synthesis. Chalcone are widely distributed in nature like fruits, vegetables, tea and spices. Which are polyhydroxylated in the aryl ring due to phenolic group and α, β unsaturated carbonyl group it shows various biological activities, such as antioxidant, antimicrobial, anti-inflammatory, anticancer. Chalcones being natural precursors are obviously important intermediates for the synthesis of flavones. From decades the chalcone had been synthesizing by conventional way of heating which has taking a long time, 24 hrs to complete, So to improve the yield and to minimize the reaction time i.e., Within a second to minutes, this review has given the various microwave assisted methods for the synthesis of chalcone derivatives with diverse structure to have maximum biological activities.