Protein and Peptide drugs have great emerging applications as healing agents because they have higher efficacy and less toxicity than chemical drugs. However, difficulty in their delivery has limited their use. In particular, their oral bioavailability and stability is very low, and non-invasive drug delivery route such as nasal, pulmonary and transdermal delivery faces absorption limitations. Therefore, the promising way of protein-based drug delivery is parenteral route. However, this route also has some problems like poor patient compliance, pain, and dermal discomfort. So, structure based nanocarriers design for drug delivery is developing nowadays and has illustrated the fewer side effects and better usefulness in disease treatment than free drug molecules. A modish nanocarriers offer site specific drug delivery in controlled fashion against all the physiological barriers and is ultimately metabolized in the body. This review will discuss the various nano- formulation strategies for biomacromolecules delivery.