Motor neuron diseases MNDS are kind of neurodegenerative diseases, specifically, it affects upper and lowers motor neurons which cause motor signals unable to pass to the exact muscles. This leads to uncontrollable twitching (fasciculations), gradual muscle weakening, wasting. and paralysis. Yet there is no permanent cure for the MNDS. After disease onset within 3-4 years death occur. Still, the therapeutic options limited despite a large number of methods have been tested clinically. Neurotrophic factor treatments known to promote faster regeneration of motor neurons and CNS neurons have been reported. However, the exact neurotrophic factor not yet finds out for clinical phase trials. In this, we discuss the underlying principle behind those neurotrophic factors and neurotrophic factor drugs for the treatment of MNDS
