In breast cancer cell cycle invasion and metastasis of aggressive are final and fetal stages during cancer progression. Therapeutically, there are few methods for the treatment of aggressive and metastatic breast cancer. Phyto-medicines are increasingly being used against cancer because of their availibity; less adverse effects, targeted, non-toxic and low cost therapy when compared with chemotherapy. The present investigation aims to examine the antiproliferative potentiality of different extracts derived from the Ficus krishnae stem bark (medicinal plant) on the growth of breast cancer cells. The F. krishnae extract directly suppress the proliferation and colony formation in breast cancer cell lines (MCF7). Meanwhile, the F. krishnae extracts did not significantly affect viability of nontumorigenic normal blood cells instead of that, it protect the blood cell from lyses due to oxygen stress. MTT assay on breast cancer cell lines i.e MCF7 shows the IC50 value of 74.46±3.1 ïg/ml, 103.38±3.3 ïg/ml, >1000ïg/ml and >1000ïg/ml of PE, CH, ME and AQ extracts respectively. Whereas the methanol extract has shown maximum protection of the blood cell from lyses was 94.59% and minimum protection at 65.18% by petroleum ether extract. The overall results concluded that the Ficus krishnae has the promising treatment for breast cancer due to presence of bioactive compounds.