In many parts of Nigeria, consumption of catfish has been regarded as part of exclusive delicacies for the upper class, although, the cost is within the rich of the majority. Catfish is one of the major sources of omega-3 fatty acids, which is a very important nutrient that protects the body against some of the most common deadly noncommunicable diseases, especially cardio-vascular diseases. Omega-3 fatty acids consist of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), which are essential fatty acids that need to be supplied regularly in human diets. This retrospective and descriptive cross-sectional survey among 259 consenting respondents and 50 catfish farmers reflected the level of acceptability of consumption of catfish and the challenges being confronted by catfish farmers. Poor awareness of the potential health benefits associated with consumption of catfish has contributed to lack of interests among the general populace. In addition, low production leading to poor availability plays a crucial role in the consumption pattern of catfish. It is important for stakeholders in catfish production to create more awareness on the potential health benefits associated with its consumption as a means of promoting public health through diets.