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On Forming Central and Peripheral Markers of Self-Tolerance Loss in Diverse Clinical Myasthenic Phenotypes | Abstract
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Abstract

On Forming Central and Peripheral Markers of Self-Tolerance Loss in Diverse Clinical Myasthenic Phenotypes

Author(s): Elena M. Klimova, Elena V. Lavinskaya, Dmitriy V. Minukhin, Anna O. Syrovaya, Larisa A. Drozdova, Anna P. Samoilova, Vitaliy V. Маkаrov, Vladimir A. Маkаrov, Larisa V. Lukiyanova

Various variants of the immune response should be used to choose an appropriate approach to the complex treatment of myasthenia and thymus affections. When specific markers are modified, there should be selected an address correction of metabolic and immunological disorders. Surgical treatment is also expedient, when tyFigureal markers of central auto-tolerance loss are present, including the high concentration of auto-antibodies to viruses, phagocyte barrier malfunctions, an insignificant increase in antibodies to the subunits of acetylcholine receptors, the high concentration of proinflammatory cytokines, a low level of regulatory CD4+CD25+cells. The preventative correction of humoral and cellular immunities will allow us to take preventative measures against complications (the auto-immune affection of other target organs) after surgical procedures (thymectomy and thymthymomectomy).


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