Acute respiratory distress syndrome (SARDS) is a severe form of acute respiratory distress SARS-CoV-2, also known as coronavirus illness of 2019, is a beta coronavirus that causes infectious respiratory disease (COVID-19). While substantial research has revealed fundamental information about COVID-19 clinical features, the illness pathophysiology remains unknown. The virus’s Receptor-Binding Domain (RBD) binds with a high affinity to the human Angiotensin-Converting Enzyme-2 (ACE-2) receptor, according to structural analyses and biochemical assays; however, the mechanism is unknown. An overview of significant results in the pathophysiology of the SARSCoV- 2 virus, as well as major pathogenicity pathways, is addressed here. Studies shed further information on how to prevent further spread of the SARS-CoV-2 virus-caused COVID-19 illness, as well as how to treat it if a similar viral epidemic strikes in the future.