The aim of present investigation was to study the therapeutic potential of Honey, Daruhaldi and Shatdhaut ghrut and honey singly and in combination on experimental excision wound healing activity in rats. Excision wounds of about 500 mm2 and 2 mm depth were used for the study. Parameters studied were period of epithelization, rate of wound contraction and time required for 50% wound closure (CT-50). Rats treated with Honey + Daruhaldi combination showed better wound healing activity as compared to other test drugs. Effect of this combination on wound area was less as compared to povidone iodine. However effect of Honey + Daruhaldi & Povidone iodine were comparable in % wound contracture or % wound closure. In this Excision wound model shatdhaut Ghrut alone or in combination with Honey showed less wound healing activity as compared to povidone iodine. The improved wound healing potential and synergistic effect of Honey & Daruhaldi can be attributed to additive antioxidant potential of Honey and flavonoid moities in Daruhaldi combination showed better wound healing potential than Honey & Daruhaldi alone.