Der Pharmacia Lettre
Faten Zahran, Mustafa Hammadi, Muayad Al-dulaimi, Mahmoud Sebaiy,
Objectives: The role of elemental sulfur in human nutrition has not been studied extensively. Therefore, this study aimed to
determine of some biochemical effects of sulfur nanoparticles (S-NPs) and emphasize the importance of this element as
antioxidant and antitumor agent.
Methods: Preparation of sulfur nanoparticles was done throughout. Firstly, the evaluation of their composition and purity by
Fourier Transform Infrared Spectrometer (FT-IR) analysis. Secondly, The shape and size of S-NPs were investigated by scanning
electron microscopy (SEM) techniques in all S-NPs samples which were prepared with Tetramethylammonium bromide (TMAB)
surfactant, Then, Energy-dispersive X-ray spectroscopy (EDS) for the evaluation of their composition and purity, After that the
X-Ray Diffraction patterns were measured for prepared S-NPs with TMAB surfactant. Final determination of sulfur
nanoparticles antioxidant and antitumor activites in experiment female mice bearing EAC, determination of some molecular
markers such as P53 and Cytochrome C. Also, histological examinations of liver and kidney tissues were done.
Results: This study revealed that sulfur nanoparticles showed high strong antioxidant activity in concentration (5 mg/kg) and
antitumor activities as it increase SOD, GPx and TAC production compared to the positive control group. Also showed a
significant increase in p53 and Cytochrome C compared with the positive control group.
Conclusion: Sulfur nanoparticles play an important role in improving oxidative stress resulted in significantly increase activity
against EAC cells, and Also, sulfur nanoparticles reduced most of the pathological alterations induced by Ehrlich ascites
carcinoma cells in mice which confirmed by histopathological examination, this may be supports the suitability of the use of
sulfur nanoparticles as an antioxidant and anticancer agent. Further, more different types of Cancer cells have unique properties
that can be exploited by nanoparticles to target this Cancer cell.