Preparation and characterization of Diacerein microcrystals | Abstract
Scholars Research Library

Scholars Research Library

Der Pharmacia Lettre


Preparation and characterization of Diacerein microcrystals

Author(s): Dhanashri Subhash Yadav, Ashwini Adhikrao Yadav, Poonam Subhash Karekar, Yogesh Vilas Pore and Pankaj Sadashiv Gajare

Diacerin (DCN) is a novel nonsteroidal anti-inflammatory drug having pharmacological properties different than classical NSAIDs. It exhibits poor aqueous solubility and slower dissolution rate. These properties were modified by novel microcrystallization technique in an attempt to enhance dissolution behaviour. Acetone and water were used as solvent and antisolvent system respectively while Poly-vinyl pyrollidone (PVPK30), Poly-ethyleneglycol 6000 (PEG 6000) and PXMR 188 (PXMR 188) were used as polymers in crystallization process. The microcrystals were characterized by XRPD (X-ray Powder Diffractometry), SEM (Scanning Electron Microscopy), FTIR (Fourier Transformation Infra-red Spectroscopy) and dissolution test. It was found that dissolution characteristics of microcrystals were significantly improved than that of pure diacerein. Also XRPD, FTIR reflected altered molecular arrangement in their structure. Thus microcrystals could be a suitable technique to improve physicochemical characteristics of diacerein.

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