Scholars Research Library

Scholars Research Library

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Preparation and evaluation of binary and ternary inclusion complex of Itraconazole

Author(s): Kamlesh Kumari, Vijay Sharma, Betty Philip, Kamla Pathak

The aim of this work was to assess the advantage of ternary complexes of itraconazole over its binary complex with ?²-cyclodextrin (?²-CD) so as to explore the possibility of further improving the solubility, dissolution rate and complexation efficiency of itraconazole -?²CD by addition of auxillary substance plasdone S-630. The phase solubility study performed in the presence of fixed amount of plasdone S-630 showed a linear, AL type diagram with a seven fold enhancement in the complexation efficiency and the stability constant was calculated as 887.60 M-1. Of the various preparation techniques used ternary complexes prepared by freeze drying exhibited highest %DE90 of 30.12. The freeze dried and microwave irradiated itraconazole -?²CD â?? plasdone S-630 terneray complexes were characterized by SEM, XRD, DSC and 1HNMR.