The need for the production of biofuels from various renewable sources is becoming increasingly interesting especially as the availability and accessibility of fossil fuels is significantly declining. Biodegradability, low pollution emissions and non-toxicity of raw materials are some properties making biogas, biodiesel and bioethanol more environmentally friendly fuels. Solid-state fermentation could be a suitable technology for the production of value-added products by utilization of the renewable waste materials, which makes it also economically feasible. So far, this technology was used for production of enzymes, organic acids, mushrooms, flavour and aroma compounds, pigments, polysaccharides, hormones, human food and animal feed. Different type of bioreactors have been developed and successfully used for solid-state fermentation of broad range of substrates and in production of value-added products. Solid-state fermentation will be demonstrated as part of anaerobic degradation on lab-, pilot- and industrial-scale of several waste materials such as brewer's spent grain, whey and cow manure, and corn silage and cow manure, respectively. The application of different microreactor systems in intensification of the biodiesel production process is widely studied. However, previous studies of the application of microreactor technology in the production of biodiesel were limited to the use of chemical catalysts. Mild reaction conditions, absence of by-products, reusability, simple separation and purification of the resulting biodiesel as well as lower energy consumption are some of the many advantages that make the enzyme lipase – a biocatalyst – a better choice than traditional chemical catalysts in the process of biodiesel production.