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Protective Effect of Centella asiatica (L.) Urban on Heart and Kidney of Rat with Subtotal Nephrectomy | Abstract
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Abstract

Protective Effect of Centella asiatica (L.) Urban on Heart and Kidney of Rat with Subtotal Nephrectomy

Author(s): Nugrahaningsih DAA, Purnomo E

Background: Centella asiatica or pegagan is one of the widely use herbal in Indonesia. Itâ??s known for its therapeutics effect for many diseases, including Chronic Kidney Disease (CKD). However, lack of study to show its effect on CKD. Objective: The aim of the study is to investigate the protective effect of Centella asiatica on heart and kidney of CKD ratsâ?? model. Methods: Twenty five rats were divided into 5 groups which were negative control group, captopril group, and 3 groups of Centella asiatica in 3 different doses. All rats were subtotal-nephrectomized and treated for 6 weeks. In the end of the treatment, the blood pressure was measured and rats were sacrificed. The heart and kidney were collected for histological examination. Result: Centella asiatica did not prevent the increase of blood pressure in CKD rat. However, the heart fibrosis, glomerulosclerosis and tubular injury score were lower in Centella asiatica group compare with those on negative control group. Conclusion: Our study shows the potency of Centella asiatica as cardio-renal protective agent in CKD.