Der Pharmacia Lettre
Lintu Mathew, C.Sankar, C.Dilip, Azeem.A.K, Abdul bari Mambra, Divya Raj, LisaMaryMani, V.Sankar, P.Vinodhini, R.Sivapathavelan, E.Balasubramanian, P.Kanniyappan
The aim of the work was to prepare a Rifampicin niosomal formulation and to compare the
entrapment efficacy and release having Cholesterol and Myristyl alcohol as membrane
stabilizers and to convert the niosome formulation into proniosome for improved stability. Six
formulations of Rifampicin niosomes were prepared with three different surfactants by thin film
hydration method using cholesterol and myristyl alcohol as membrane stabilizers. The niosomal
suspensions were evaluated for size analysis, drug entrapment and invitro release.
Lyophilization was also performed for niosomal formulation. Rifampicin proniosome were
prepared by thin film hydration method using mannitol as carrier with surfactant Span20. The
formulations of span 40 with myristyl alcohol and span 20 with cholesterol showed higher
entrapment efficiency. Invitro drug release from span 20 formulations with cholesterol was
found to be slower than with the formulation containing span 40 with myristyl alcohol. The study
proves that the membrane stabilizing activity of cholesterol shows the feasibility of storing
niosomal suspension in the form of proniosomes for a longer duration.