One of the major problems in patients undergoing chronic hemodialysis is sleep disorders, and potentially predictor of mortality and quality of life in these patients. Therefore, this study is evaluated sleep disorders in the city of Zabol in hemodialysis patients. This is a cross-sectional study on 37 patients with chronic hemodialysis in Zabol University of Medical Sciences at least six months passed of their hemodialysis treatement and did hemodialysis 3 times a week between three and four hours. Data collection tool in this study was a questionnaire based on the Epworth Sleepiness Scale drowsiness, insomnia Sleepiness Scale Pittsburgh and standard interview form was prepared and also valid questionnaires Post Sleep Inventory Modified (PSI) to coincide with the completion of questionnaires from patients to measure blood levels of uric acid, creatinine, calcium, thyroid hormones, CRP and PTH. Collected data was analyzed by SPSS software. The results showed that in general, 99.4% of subjects had sleep disorder, meaning that 72.9 % had delay in falling asleep, 66.3% had frequent awakening during sleep, 43.2% had waking up early in the morning, 43.2% feel sleepy during the day and 4.48% of patients had fatigue during the day. According to the findings of this study, hemoglobin, iron, calcium, CRP, urea, creatinine, TSH, T4, phosphorus, and PTH albumin had no significant correlation with sleep disorders; while uric acid and T3 had inverse correlation with sleep disorders. (p=0.01 and 0.012). Sleep disorders are a common phenomenon in hemodialysis patients. It can affect patients' psychological and social performance. It seems that according to the results, it is suggested to focus attention on the treatment and care of patients undergoing chronic hemodialysis for sleep disturbances by nursing.