The purpose of this study was to improve the solubility and dissolution rate of domperidone (DOM) by preparing its multicomponent inclusion complex. Inclusion complexes of DOM were prepared by kneading method along with β-cyclodextrin (β-CD) using polyvinyl pyrrolidone (PVP K40) and citric acid. Phase solubility studies were conducted to monitor the formation of complex and effect of water soluble polymers and citric acid on solubility of DOM. The prepared complexes were characterized by differential scanning calorimetry, fourier transform infrared spectroscopy, scanning electron microscopy, optical microscopy, X-ray diffractometry and nuclear magnetic resonance spectroscopy. Water soluble polymers synergistically enhanced solubilizing efficiency of β-CD and solubility of DOM in presence of citric acid.