Der Pharmacia Lettre
Narendra Kr. Goyal, Nitin Sharma, P. K. Sharma
Direct tabletting technique is the modern and the most efficient process used in tablet
manufacturing which has been successfully used for various drugs. But the process strongly
depends upon the quality of the crystals used. For improvement of direct compression properties
of different poorly soluble drugs Kawashima and their coworkers developed the spherical
crystallization technique in 1986, for size enlargement of the drug in the field of pharmacy.
Agglomeration technique can transform directly the fine crystals, produced in the crystallization
process into a spherical shape. Spherical crystallization is a particle design technique, by which
crystallization and agglomeration can be carried out simultaneously in one step. This technique
has been successfully utilized for improvement of powder properties such as particle size, shape
and flow properties of crystalline drugs. Solubility enhancement of pharmaceutical drug is also
investigated by spherical crystallization. In this review we will discuss about the advantages,
method and parameters which can be improved by spherical crystallization process. In addition
current and future prospects of spherical crystallization are also discussed.