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Statistical optimization of mucoadhesive ketoprofen multiparticles to target the small intestine | Abstract
Scholars Research Library

Scholars Research Library

Der Pharmacia Lettre

Abstract

Statistical optimization of mucoadhesive ketoprofen multiparticles to target the small intestine

Author(s): Sivakumar Ramakrishnan*, Rajendran N and Narayanan N

The aim of the study was to apply statistical optimization technique for the development of ketoprofen loaded mucoadhesive multiparticles to target the small intestine. The mucoadhesive multiparticles were prepared by quassi- emulsion solvent diffusion method and filled in enteric coated capsules. All the formulations were characterized for particle size, mucoadhesion, drug loading, entrapment efficiency, in vitro release studies. A 32 factorial design was used to optimization. The dependable variables were PVA concentration (X1) and rotational speed of stirring elements(X2). The chosen response variables were particle size (Y1), percentage of drug release for 24 h (Y2), mucoadhesion (Y3) and entrapment efficiency (Y4). The optimized formulation according to the study was mucoadhesive microspheres prepared with 0.5% w/v of PVA and 400 rpm of stirring speed i.e ( -1, +1). The results of this optimized formulation showed with mean particle size of 225.5 ?¼m, percentage of drug release for 24 h 97%, 83.43% of mucoadhesion and 88.4% of entrapment efficiency.

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