Foeniculum vulgare (fennel) belong to Apiaceae family has been used in traditional medicine for many therapeutic purposes. The aim of this study was to overview its therapeutic effects than its nutritive and industrial effects. This review article was carried out by searching studies in PubMed, Medline, Web of Science, and IranMedex databases .The initial search strategy identified about 114 references. In this study,39studies was accepted for further screening and met all our inclusion criteria [in English, full text, therapeutic effects of Foeniculum vulgare L and dated mainly from the year 1985 to 2016.The search terms were “Foeniculum vulgare L.”, “therapeutic properties”, “pharmacological effects”. It is commonly used for its anti-bacterial, anti-fungal, antimicrobialand antimycobacterial, antioxidant effects. It was said to be good for insomnia and dyssomina. Foeniculum vulgare l is a rich plant .although in many studies, its anti-microbial activities were confirmed, more studies are still needed to verify its potent effect.