Mentha pulegium, commonly pennyroyal, also called squaw mint, mosquito plant and pudding grass, is a species of flowering plant in the family Lamiaceae native to Europe, North Africa, and the Middle East.The aim of this study was to overview its therapeutic effects than its nutritive and industrial effects. This review article was carried out by searching studies in PubMed, Medline, Web of Science, and Iran Medex databases .The initial search strategy identified about 128 references. In this study, 113 studies was accepted for further screening and met all our inclusion criteria [in English, full text, therapeutic effects of Mentha pulegium and dated mainly from the year 1964 to 2015.The search terms were “Mentha pulegium.”, “therapeutic properties”, “pharmacological effects”. It is commonly used for itsmetabolism, Acaricidal effects, hepatotoxicity, anti-hepatic, antibacterial activity, antioxidant effect, Anti-steel corrosion, relaxant effects, spasmolytic effect, Anti-genotoxic effects, antimicrobial activity, antimyometrium. Mentha pulegiumlis a plant of high significance.