Ocimum basilicum, Ocimum basilicum, also called great basil or Saint-Joseph's-wort, is of family Lamiaceae (mints) .Basil is possibly native to India. The aim of this study was to overview its therapeutic effects than its nutritive and industrial effects. This review article was carried out by searching studies in PubMed, Medline, Web of Science, and Iran Medex databases .The initial search strategy identified about 98 references. In this study, 37 studies was accepted for further screening and met all our inclusion criteria [in English, full text, therapeutic effects of Ocimum basilicum, and dated mainly from the year 1998 to 2016.The search terms were “Ocimum basilicum,”, “therapeutic properties”, “pharmacological effects”. It is commonly used for anti-osteoporotic effect .anxiolytic and sedative effect, Anti-colitis effect, antibacterial activity, cytotoxic activity, cardiovascular disease, antihepatotoxicity effect, antioxidant capacity, Phytoremediatory effect, hypoglycemic effect, antihypertensive effects, vasorelaxant and anti-platelet effect, anti-inflammatory effect, Anti-thrombotic effect, synergistic effects, insecticidal fumigant.