Organophosphate poisoning is encountered as an emergency problem in rural areas. OP poisoning can result from accidental ingestion and self-poisoning. This study was to evaluate patients diagnosed with organophosphate poisoning, to study the type of compound, its clinical features and to correlate prognosis of the organophosphate compound.The study was conducted for a period of 6 months [March 2016 to September 2016] in Rajah Muthiah Medical College Hospital, Annamalai University,1200 bedded multi-specialty tertiary care teaching hospital located in Tamil Nadu. All relevant data were collected from inpatient case records. A total of 100 patients were taken for this study. A total number of 100 patient’s data were analyzed,in which majority of them were males (66%).The most affected age group were31-50 years (44%) in males and 18-30 years (50%) in females. The most common organophosphate compound is Monocrotophos and the least were Porphyrous, Dimethoate and Quinalophos.The most consistent clinical manifestations was vomiting and the least were fasciculation, pinpoint pupils and urination. Mortality rates were higher in patients who consumed higher amount of poison on empty stomach and delayed presentation to hospital. This study reveals that early diagnosis, effective management and establishing poison information center will reduce the mortality rates.