Scholars Research Library

Scholars Research Library

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Annals of Biological Research

Abstract

Study of synergistic anti-inflammatory activity of Murraya koenigii and Aegle marmelos

Author(s): D. Susanna, D. Bhavana, D. Mounika, V. Sandhya, D. Vijay Anand Raju, R. Nagakishore and Bolay Bhattacharya

The curry leaf tree is native to India, Sri Lanka, Bangladesh and the Andaman Islands. The leaves are particularly associated with South Indian famous cuisines. The study investigate the anti-inflammatory  activities of  the  leaves  of Murraya.  Aegle marmelos has been used as a herbal medicine for the management of diabetes mellitus in Ayurvedic, Unani and Siddha systems of medicine in India Bangladesh and Sri Lanka. Methanolic extracts were prepared separately from Murraya koenigii & Aegle marmelos. Individual & synergistic anti-inflammatory activity of both the plants were studied by carrageenan induced inflammation & paw edema on albino wistar rats. Individual doses of above two extracts produced anti-inflammatory property. But combined doses of above two extracts produced pronounced synergistic anti-inflammatory activity. When combined dose is increased the degree of inhibition is much better & comparable to reference drug. The carrageenan induced paw edema test is effectively controlled with the arachidonate cyclooxygenase (COX) inhibition suggesting that the MEMK and MEAB may possess arachidonate COX inhibitory property. These extracts can be used to isolate pure compound that can be utilized for rational designing of anti-inflammatory drugs with significant synergism


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