Scholars Research Library

Scholars Research Library

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Der Pharmacia Lettre

Abstract

Synthesis and Evaluation of Anti-tuberculosis Activity of Substituted 4-(1HIndol-3-yl)-1,6-Diphenyl-5,6-Dihydropyrimidin-2 (1H) One Derivatives

Author(s): Buvana C, Suresh R, Haribabu Y, Manna PK

In the present study novel pyrimidine derivative of 4-(1H-indol-3-yl)-1, 6-diphenyl-5,6-dihydropyrimidin-2 (1H) one were synthesized and evaluated for their in vitro anti tuberculosis activity. A series of chalcones from indole-3-carbaldehyde and substituted aromatic ketone was synthesized and cyclo condensed with phenyl urea to give indoyl-pyrimidone derivatives. All synthesized compounds were characterized by IR spectroscopy and purification determined by melting point and TLC. Compounds were evaluated for their anti-tuberculosis activity against mycobacterium tuberculosis (H37RV Strain). Among the synthesized compounds IP-2 and IP-3 exhibited 6.25 µg/ml and found to be significant in activity when compared with standard drug (3.12 µg/ml).


javgrown.com scatvids.club javvids.com