Scholars Research Library

Scholars Research Library

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Der Pharmacia Lettre


Synthesis, Characterization and Antimicrobial Activity of Novel Benzimidazole Molecule

Author(s): Shabista Khan, F.B.Bux, Arun Singh

The reaction between benzimidazole with N-[4-(2-chloroacetyl)phenyl]acetamide affords N-[4- (2-(1H-benzimidazol-1-yl) acetyl] phenyl acetamide,which upon hydrolysis yield 1-(4- aminophenyl)-2-(1H-benzimidazol-1-yl)ethanone. The Diazotion of 1-(4-aminophenyl)-2-(1Hbenzimidazol- 1-yl)ethanone couple with salicylic acid,they afford the ligand compound and named as 5-([4-(2-(1H-benzimidazol-1-yl)acetyl)phenyl]diazenyl)-2-hydroxybenzoic acid(SABI). The transition metal complexes of Cu2+, Co2+ ,Ni2+, Mn2+ and Zn2+ of SA-BI have been prepared and characterized by elemental analyses, spectral studies, magnetic moment determination, molar conductivity measurement and microbicidal activity.