Scholars Research Library

Scholars Research Library

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Synthesis, Characterization and Evaluation of Novel substituted benzo-indolylidene acetohydrazide Derivatives as Anti-Microbial Agents

Author(s): Gummadi Sridhar Babu, Thatiparthy Swathy, Puttireddy S Malathy, Bethi Srinivas, Umasankar Kulandaivelu, Jupally Venkateshwar Rao , Neralla Raghunandan

A series of benzo-indolylidene acetohydrazides were synthesized by condensation of 2-chloro-N- [2-oxo-1,2-dihydro-3H-benzo[g]indol-3-ylidene]-acetohydrazide with various amines and tested for their antibacterial activities against various Gram-positive and Gram-negative bacteria and antifungal activity against the fungus Candida albicans and yeast. The synthesized compounds 6a-6f was characterized by spectral data (IR, NMR and mass) and elemental analysis. All compounds were screened for their antibacterial and antifungal activity by Cup-plate method (disc method). The Compounds 6e and 6f, showed considerable enhanced antibacterial activity against all microorganisms. Microbiological results indicated that the synthesized compounds possessed a broad spectrum of activity against the tested microorganisms.