Scholars Research Library

Scholars Research Library

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Der Pharmacia Lettre

Abstract

Synthesis, Characterization and Evaluation of Novel substituted benzo-indolylidene acetohydrazide Derivatives as Anti-Microbial Agents

Author(s): Gummadi Sridhar Babu, Thatiparthy Swathy, Puttireddy S Malathy, Bethi Srinivas, Umasankar Kulandaivelu, Jupally Venkateshwar Rao , Neralla Raghunandan

A series of benzo-indolylidene acetohydrazides were synthesized by condensation of 2-chloro-N- [2-oxo-1,2-dihydro-3H-benzo[g]indol-3-ylidene]-acetohydrazide with various amines and tested for their antibacterial activities against various Gram-positive and Gram-negative bacteria and antifungal activity against the fungus Candida albicans and yeast. The synthesized compounds 6a-6f was characterized by spectral data (IR, NMR and mass) and elemental analysis. All compounds were screened for their antibacterial and antifungal activity by Cup-plate method (disc method). The Compounds 6e and 6f, showed considerable enhanced antibacterial activity against all microorganisms. Microbiological results indicated that the synthesized compounds possessed a broad spectrum of activity against the tested microorganisms.
javgrown.com scatvids.club javvids.com