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Synthesis of Acetylamino-Thiadiazoline Derivatives and In-Vitro screening of their antifungal activities | Abstract
Scholars Research Library

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Abstract

Synthesis of Acetylamino-Thiadiazoline Derivatives and In-Vitro screening of their antifungal activities

Author(s): Mohammad Russell* and Mohammad Ikthair Hossain Soiket

Synthesis of Schiff’s base 1-[(2, 4-difluorophenyl)-2-(1H-1, 2, 4-triazol-1-yl)] ethanone thiosemicarbazone (1A) prepared by condensation of 1-(2,4-difluorophenyl)-2-[1(H)-1,2,4-triazol-1-yl] ethanone with thiosemicarbazide, followed by cyclization to 2-(2,4-difluorophenyl)-2-[(1H)-1,2,4-triazol-1-ylmethyl)]-3-acetyl-5-acetylaminothiadiazoline (2A) using acetic anhydride and finally hydrolysis of (2A) to form 2-(2,4-difluorophenyl)-2-[(1H)- 1,2,4-triazol-1-ylmethyl)]-3-acetyl-5-amino-thiadiazoline (3A) using hydrazine hydrate, all compounds having antifungal activities are reported.


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