Chalcones are important starting materials for the synthesis of various classes of five, six and seven memberd heterocyclic compounds. most of these compounds are highly bioactive and are widely used in pharmaceuticals. they belong s to an important class of flavonoids, Chalcones are synthesized by Claisen–Schmidt condensation, which involves cross aldol condensation of appropriate aldehydes and ketones by base or acid catalysed reactions followed by dehydration. 12 new Chalcones were synthesized by conventional and microwave assisted synthesis methods. The structures of newly synthesized compounds were confirmed by spectral evidence.microwave assisted synthesis, a considerable increase in the reaction rate has been observed and that too, with better yields. Prepared compounds were tested for anto microbial activity.