Humans are always exposed to environmental microbes, the micro biome studies that have under scored the trust of mammalian systems on appropriate microbial colonization to support metabolic and immune homeostasis. Chronic inflammatory disease including allergy, have increased dramatically over the past decades. The role of the Treg in defining both the local and systemic immune response, also in GI response to pathogenic microbes is important. In this review, we examined the role of regulatory T cells in Gut and whole body homeostasis.
