Intracellular adhesion molecule-1 (sICAM-1) is one of the factors associating obesity and inflammatory lesions like atherosclerosis. The purpose of the present study was to investigate the effects of continues and intermittent training on serum levels of sICAM-1 in sedentary young women. For this purpose, 30 female overweight volunteer students (BMI ≥ 26) of Azad University Shahre Qods Campus were selected and randomly divided into three groups: continues and intermittent training group and control group. Training groups exercised for 12 weeks, three sessions a week with definite intensity and distance. ICAM, body weight, fat percentage, BMI And maximum oxygen consumption were measured both before and after the 12-week exercise. Results showed that continue and intermittent training caused a significant decrease in sICAM-1, weight and body composition, significant increase in Vo2max of the experimental groups in comparison to control group. Our findings showed that with significant reduction of sICAM-1 levels and decreasing inflammation, continue and intermittent exercise may perhaps play an effective role in prevention, control and mitigation of atherosclerosis.